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Abstract #2453

Parahydrogen Induced Polarization of Barbituric Acid Derivatives. 13C Hyperpolarization Studies

Meike Roth1, Kerstin Mnnemann1, Joachim Bargon2, Hans Wolfgang Spiess1, Achim Koch1

1Max Planck Institute for Polymer Research, Mainz, Germany; 2Institute of Physical and Theoretical Chemistry, University of Bonn, Germany

NMR signal enhancement by PHIP techniques is interesting for spectroscopic investigations and may also find applications in MRI, which is of great importance for medical diagnostics. Hence, the role of certain target compounds such as anesthetics could be investigated by using MRI techniques. Among the drugs used to treat epilepsy or for injection narcotics, barbiturates like 5-methyl-5-propargylbarbituric acid are attractive from the medical and chemical point of view. By combining the PH-INEPT+ sequence with a PASADENA experiment under pressure of unsaturated barbituric acid derivatives a transfer of polarization to 13C was implemented yielding a dramatic signal increase of up to 1000.