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Abstract #2493

Brain Capillary Water Permeability from Proton Density 1H2O Imaging in the Rat During Deuterated Saline Bolus Passage

Audrey H. Selzer1, William D. Rooney1, Thomas M. Barbara1, James A. Goodman1, Charles S. Springer Jr. 1, Xin Li1

1Advanced Imaging Research Center, Oregon Health and Science University, Portland, OR, USA

In vivo intercompartmental water exchange has been studied extensively using labeled water. Here we use proton imaging to monitor the 2HOH concentration change during a bolus injection of deuterated saline solution, and thence measure non-equilibrium transendothelial water transport. This provides a direct comparison of MRI results of water transport with those from other methods.