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Abstract #2496

About the Limitations of the PS-Limited Tofts Model

Guido Correia Carreira1, Dirk Beyersdorff2, Lutz Luedemann3

1Radiology, Charite Medical School, Berlin, Germany; 2Radiology, Bethel Hospital, Berlin, Germany; 3Charite Medical School, Germany

Little systematic work has been done on the limitations of compartment models. This work shows that compartment models may indicate a variation of vessel permeability and extracellular fractional volume even when there is no such change in these tissue parameters, but in different ones like for example vessel distance. To this end, numerical diffusion simulations for several tissue models, describing the CM distribution process at the microscopic scale, are compared with a standard PS-limited (low permeability) two-compartment Tofts model.