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Abstract #2543

MRI-Guided Focused Ultrasound (MRgFUS) System for Thermal Ablation of Prostate Cancer: Pre-Clinical Evaluation in Canines

Nathan McDannold1, Hadas Ziso2, Benny Assif2, Arik Hananel2, Natalia Vykhodtseva1, Peri Gretton2, Magdalini Pilatou1, Steve Haker1, Clare Tempany1

1Harvard Medical School, Brigham & Women's Hospital, Boston, MA, USA; 2InSightec, Haifa, Israel

A transrectal MRgFUS system was tested in a canine prostate model. Focal volumes in each half of the prostate were targeted, with high energy in one half of the gland for ablation and on the other with lower-energy sonications to test our ability to localize the focal spot before causing thermal tissue damage. All sonications (n=155) were readily observed with proton resonance frequency (PRF) MR temperature imaging, contrast enhanced MRI and histology. The prostate gland moved during the experiments. The resultant focal temperature changes were 24.28.2C.