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Abstract #2635

Robust T1 Mapping in the Presence of Partial Volume Effects

Vasiliki N. Ikonomidou1

1Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA

Partial volume effects can cause significant errors in T1 estimation. This makes measurement of T1 difficult at the interfaces between brain tissue and cerebrospinal fluid (CSF), such as the cortex. This study presents an optimized technique that combines a saturation and an inversion pulse in order to keep CSF signal suppressed, and allows fitting T1 in a range corresponding to brain tissue while minimizing partial-volume induced error, in a total scantime of 3 minutes.