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Abstract #2698

MP2RAGE Contrast Optimization at 7T and Applications

Jos Pedro Marques1,2, Tobias Kober1,3, Gunnar Krueger3, Wietske van der Zwaag1,2, Pierre-Franois van de Moortele4, Rolf Gruetter1,2

1Centre d'Imagerie BioMdicale, CIBM, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland; 2Dpartement de Radiologie, Universit de Lausanne, Lausanne, Vaud, Switzerland; 3Advanced Clinical Imaging Technology, Siemens Medical Solutions-CIBM, Lausanne, Vaud, Switzerland; 4CMRR, University of Minnesota, Minneapolis, MN, USA

In this work, the contrast of the MP2RAGE sequence was optimized for brain tissues at 7T. This contrast is fully independent of B1-, T2* and proton density. Following the protocol described on the abstract, it can be made virtually B1+ insensitive and therefore usable to estimate T1. The proposed contrast is suitable for applications such as image segmentation given its ability to separate CSF, GM and WM even in whole brain histograms.