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Abstract #2700

Measuring the Cerebro-Spinal Fluid Temperature Using Diffusion MRI

Zoltan Nagy1, Lajos R. Kozak2, Marta Bango3, Miklos Szabo3, Rudas Gabor2, Zoltan Vidnyanszki2

1Wellcome Trust Centre for Neuroimaging, University College London, London, UK; 2Szentagothai J. Knowledge Centre, MR Research Centre, Semmelweis University, Budapest, Hungary; 3First Department of Pediatrics, Semmelweis University, Budapest, Hungary

While hypothermia is used as a neuroprotective method after stroke, cardiac arrest or traumatic brain injury, and elevated body temperature increases the risks of convulsions and worsening of brain injury. However, in clinical practice the actual brain temperature in these cases is either estimated indirectly from measurements elsewhere in the body or with invasive methods. We developed a protocol which is based on diffusion weighted MRI to estimate the temperature of the CSF within the lateral ventricles of the brain. Knowledge of the brain temperature may improve the protocols for induced hypothermia in patients.