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Abstract #2750

19F Signal Amplification by Heteronuclear Polarization Transfer

Florian Schmid1, Manuel Tsotsalas2, Michael Kuhlmann3, Carsten Hltke1, Christoph Bremer1, Walter Heindel1, Andres Guerrero-Martinez2, Jochen Keupp4, Michael Schfers3, Luisa De Cola2, Cornelius Faber1

1Institute for Clinical Radiology, University Hospital Mnster, Mnster, Germany; 2Physikalisches Institut and NRW Graduate School of Chemistry, Westflische Wilhelms-Universitt Mnster, Mnster, Germany; 3European Institute for Molecular Imaging, Westflische Wilhelms-Universitt Mnster, Mnster, Germany; 4Philips Research Europe, Hamburg, Germany

Signal enhancement by NOE was investigated in 19F-MRI using 2-Fluoro-2-deoxy-D-glucose (FDG) and 2,2,2-Trifluoroethanol (TFE). The 19F signal was considerably increased by steady-state NOE preparation in spectroscopy and imaging sequences. TFE was loaded in novel potential carriers of contrast agents, zeolite L crystal nanocontainers. FDG was applied to mice and 19F images of the fixed mouse heart could be aquired at a clinical MRI scanner at 3T.