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Abstract #2757

CRAZED Signal Dependence on Correlation Distance and Sample Orientation in Rat Sciatic Nerve

Arman S. Kussainov1, Mark D. Does2, Nellie E. Byun3, John C. Gore1,3, Daniel F. Gochberg1,3

1Physics, Vanderbilt, Nashville, TN, USA; 2Biomedical Engineering, Vanderbilt, Nashville, TN, USA; 3Radiology, Vanderbilt, Nashville, TN, USA

We measured the CRAZED signal from ex vivo rat sciatic nerve while varying the sample orientation and the gradient induced correlation distance, and we compared these results to a doped water cylindrical sample of the same size but lacking any internal structure. The results for the sciatic nerve have characteristics indicative of cylinders at both the ten and hundreds of micrometers distance scales, reflecting both axon and the tibial/peroneal fascicle structures that compose the nerve. These results support the view that CRAZED methods are able to probe a range of distance scales not available in other magnetic resonance methods.