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Abstract #2900

Establishing Probabilistic Chinese Human Brain Templates Using HAMMER Elastic Registration Algorithm

Zhentao Zuo1, Xing Wang2, Nan Chen2, Jing Luo1, Yan Zhuo1, Dinggang Shen3, Kuncheng Li2, Rong Xue1

1State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; 2Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China; 3Department of Radiology & BRIC, School of Medicine, University of North Carolina, Chapel Hill, NC, USA

We have successfully constructed Chinese human brain templates for male and female groups using the HAMMER automatic deformable registration algorithm. Sharp white matter and gray matter boundaries and brain ventricular edges of the templates were displayed compared with other normalization results. The average Chinese human brain templates had smaller brain volumes but wider brain shape than the MNI templates of the western society. In the future, we would further apply the HAMMER registration algorithm to a larger data set of Chinese people and generate the probabilistic Chinese brain templates, to promote the establishment of digitized standard brain (DSB) database for fMRI and disease-related neuroscience studies in China.