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Abstract #2909

Quantitative Comparison of Methods for Spatial Normalisation of CASL Perfusion MR Images

Stephen J. Wastling1, Owen O'Daly2, Fernando O. Zelaya2, Matthew Howard2, David C. Alsop3, Ruth L. O'Gorman2,4

1Medical Engineering and Physics, King's College Hospital, London, UK; 2Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK; 3Neuroradiology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 4Neuroradiology, King's College Hospital, London, UK

This study quantitatively examined the accuracy and precision of various registration software methods, cost functions, and templates for the spatial normalisation of continuous ASL (CASL) perfusion MRI data. While the registration precision was broadly comparable across all methods, the registration accuracy varied considerably, although several methods yielded registrations accurate to 1 mm or less.