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Abstract #3031

Efficacy of Diphenhydramine in the Prevention of Vertigo and Nausea at 7 Tesla

Markus Thormann1, Jens Ricke1, Astrid Wollrab1, Daniela Adolf2, Oliver Speck1

1Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany; 2Biometrics and Medical Informatics, Otto-von-Guericke University, Magdeburg, Germany

In recent years the number of Ultra-High-Field-MR-Scanners is increasing. The most frequently reported side effects at 7-Tesla are vertigo and nausea during table motion. The purpose of this study was to test whether Diphenhydramine can improve patient comfort and the subjective acceptance of high field MR-scanners by preventing vertigo and nausea. In a prospective, double blinded, placebo controlled, cross-over randomized study we quantified the sensations of 30 volunteers before and after exposure to the static magnetic field with and without drug respectively placebo administration. A reduction of the strength of vertigo and a prevention of nausea is possible.