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Abstract #3134

Novel Perfluorocarbon Nanoemulsion for 19F MRI Cell Tracking of Two Cell Populations in Vivo

Jelena M. Janjic1, Deepak K. Kadayakkara1, Lisa K. Pusateri1, Eric T. Ahrens1,2

1Carnegie Mellon University, Pittsburgh, PA, USA; 2Pittsburgh NMR Center for Biomedical Research, Pittsburgh, PA, USA

A novel, non-toxic 19F tracer reagent, perfluorotertbutylether (PFTE) nanoemulsion, suitable for ex vivo cell labeling and in vivo imaging is described. The feasibility of multi-spectral 19F MRI using PFTE and perfluoro-15-crown-5 ether (PCE) to visualize two cell populations in vivo is demonstrated. The development of the new PFTE nanoemulsion opens up the possibility to study immune cell-cell interactions in vivo using MRI.