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Abstract #3139

Potential Application of Hyaluronic Acid in MR Imaging

Wenlian Zhu1, Dmitri Artemov1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA

CD44 is a recognized target in caner therapy. Here we attempted to use hyaluronic acid (hyaluronan or HA), a major CD44 ligand as a probe to access the CD44 status of breast cancer cells. We also investigated the possibility of using HA gadolinium conjugate as a blood pool MR contrast agent. Preliminary results demonstrated the potential of HA as a CD44 targeting moiety as well as a macromolecular contrast agent carrier.