Praveen Gulaka1, Tina Darjazanie2, Ralph P. Mason2, Vikram D. Kodibagkar2
1Biomedical Engineering, UT Southwestern Medical Center at Dallas, Dallas, TX, USA; 2Radiology, UT Southwestern Medical Center at Dallas, Dallas, TX, USA
The ability to quantitatively measure tissue oxygen tension (pO2) non-invasively may have a significant impact on understanding mechanisms of tissue function and in clinical prognosis of disease. The linear dependence of R1 of fluorocarbon 19F NMR resonances on pO2 has been studied extensively. Hexamethyldisiloxane (HMDSO) has been previously identified as an analogous 1H based pO2 reporter molecule by in vivo spectroscopy and imaging (PISTOL technique). We now present data demonstrating the calibration of HMDSO based nanoemulsions and mapping tissue oxygenation in response to oxygen challenge following intra tissue injection of these emulsions.