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Abstract #3152

Quantitative Molecular Imaging with a Dual Modality MR and Fluorescence Diffuse Optical Imaging System: Phantom Study

Yuting Lin1, Han Yan1, Orhan Nalcioglu1, Gultekin Gulsen1

1Center for functional onco imaging, University of California, Irvine, CA, USA

Quantitative molecular imaging is essential in many applications. An ideal molecular imaging technique should have both high sensitivity for molecular probes and also provide high-resolution images. Our solution to this demanding requirement is to employ a multimodality imaging strategy. In this study, a CCD based non contact fluorescence tomography system was built. We constructed multi-modality phantoms with MRI contrast agent, Gd-DTPA, and optical contrast agent, ICG. Our result shows that the true fluorophore concentration can only be recovered when both modalities are employed. In the future, this combined system has a great potential for quantitative molecular imaging.