Quantitative Molecular Imaging with a Dual Modality MR and Fluorescence Diffuse Optical Imaging System: Phantom Study

Yuting Lin¹, Han Yan¹, Orhan Nalcioglu¹, Gultekin Gulsen¹

Quantitative molecular imaging is essential in many applications. An ideal molecular imaging technique should have both high sensitivity for molecular probes and also provide high-resolution images. Our solution to this demanding requirement is to employ a multimodality imaging strategy. In this study, a CCD based non contact fluorescence tomography system was built. We constructed multi-modality phantoms with MRI contrast agent, Gd-DTPA, and optical contrast agent, ICG. Our result shows that the true fluorophore concentration can only be recovered when both modalities are employed. In the future, this combined system has a great potential for quantitative molecular imaging.