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Abstract #3166

Nanoparticle Detection of Vascular Inflammation in Mouse Carotid Artery at 7T

Hisanori Kosuge1, Masahiro Terashima1, Masaki Uchida2, Sarah Sherlock3, Philip S. Tsao1, Mark J. Young2, Trevor Douglas2, Hongjie Dai3, Michael V. McConnell1

1Cardiovascular Medicine, Stanford University, Stanford, CA, USA; 2Chemistry and Biochemistry, Montana State University, Bozeman, MT, USA; 3Chemistry, Stanford University, Stanford, CA, USA

Inflammation plays a critical role in the progression of atherosclerosis. Magnetite incorporated human ferritin protein cages and graphite/FeCo core-shell nanocrystals may allow noninvasive high-field MRI detection of vascular macrophages in mouse arteries. We demonstrate that MRI at 7T can detect vascular macrophages with magnetite protein cage nanoparticles and graphite/FeCo core-shell nanocrystals in mouse atherosclerotic lesions.