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Abstract #3168

MRI Detection of Progenitor Cell Migrations During Postnatal Rat Brain Development by in Situ MPIO Labeling

Jian Yang1,2, Jianxin Liu3, Gang Niu1, Rong Wang1, Yong Liu4, BoLang Yu1, Ed Xuekui Wu2

1Medical Imaging Center of The First Hospital, The School of Medicine,Xi'an Jiaotong University, Xi'an, China; 2Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China; 3Institute of neurobiology, The School of Medicine, Xi'an Jiaotong University, Xi'an, China; 4Institute of neurobiology, The School of Medicine, Xi'an Jiaotong University,, Xi'an, China

In this study, micron-sized iron oxide particles (MPIOs) were injected into the left anterior lateral ventricle of 10-day-old normal rats. T2- and T2*-weighted images were acquired using a 7T scanner at day 1, 3, 7 and 14 after the MPIO injection. Histological analyses were then performed to identify MPIOs in different migrating cells, namely, neural progenitor and astrocytes-like progenitor cells. The migrating pathways of the MPIO-labeled endogenous progenitors exhibited a predominantly bidirectional, rostrocaudal pattern in tangential orientation. Such in situ MPIO labeling approach opens the possibility of using MRI to study the mechanism of cell migration in developing brain.