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Abstract #3173

Gd-Containing Dendrimer as a Novel T1-Weighted Lung MRI Contrast Agent

Wen-Yuan Hsieh1, Dhakshanamurthy Thirumalai2, Chien-Yuan Lin3, Sui-Shan Lin3, chen Chang3, Shin-Shin Shen4, Jassy Wang2

1Material and Chemical Research Laboratories, Industrial Technology Research Institute , Hsinchu, taiwan, Taiwan; 2Material and Chemical Research Laboratories, HsinJu, Taiwan; 3Academia Sinica, Taipei, Taiwan; 4Biomedical Lab, HsinJu, Taiwan

Synthesis of a novel and hitherto unknown starburst Gd-containing dendritic contrast agent from pentamethylcyclopentasiloxane and polyethylene glycol (PEG) and its contrast enhancement on the lung tissue of mice during MR imaging were described. This study present great enhancement of lung imaging using MRI with novel T1 contrast agnet.