Abstract #3173

Gd-Containing Dendrimer as a Novel T1-Weighted Lung MRI Contrast Agent

Wen-Yuan Hsieh¹, Dhakshanamurthy Thirumalai², Chien-Yuan Lin³, Sui-Shan Lin³, chen Chang³, Shin-Shin Shen⁴, Jassy Wang²

¹Material and Chemical Research Laboratories, Industrial Technology Research Institute , Hsinchu, taiwan, Taiwan; ²Material and Chemical Research Laboratories, HsinJu, Taiwan; ³Academia Sinica, Taipei, Taiwan; ⁴Biomedical Lab, HsinJu, Taiwan

Synthesis of a novel and hitherto unknown starburst Gd-containing dendritic contrast agent from pentamethylcyclopentasiloxane and polyethylene glycol (PEG) and its contrast enhancement on the lung tissue of mice during MR imaging were described. This study present great enhancement of lung imaging using MRI with novel T1 contrast agnet.