Abstract #3175

Intra-Individual In-Vivo Comparison of Gd-Contrast Agents for Quantitative Pharmacokinetic Analysis Using Dynamic Contrast Enhanced MR Imaging

Jiachao Liang¹, Steffen Sammet¹, Xiangyu Yang¹, Guang Jia¹, Yukihisa Takayama², Michael V. Knopp¹

¹Department of Radiology, The Ohio State University, Columbus, OH, USA; ²Department of Clinical Radiology, Kyushu University, Fukuoka, Japan

The usefulness of magnetic resonance (MR) imaging contrast agents to improve visualization of brain imaging is firmly established. Gadoliniumbased MR contrast agents have been approved by the US FDA for MR imaging procedures. Numerous intraindividual comparative studies within different Gd agents at equivalent dose and equivalent magnetic field strength, from 1.5T to 3T, have been investigated. This study evaluates the signal intensity characteristics of dynamic contrast enhanced MR imaging (DCE-MRI) at ultra-high field (7T) in a preclinical beagle brain study with different contrast agents, different injection rates and different injection dosages.