Behrang Amini1, Glyn Johnson2, James S. Babb2, Joseph Herbert3, Robert I. Grossman4, Matilde Inglese5
1Radiology, Tufts Medical Center, Boston, MA, USA; 2Radiology, New York University, New York, NY, USA; 3Neurology, New York University, New York, NY, USA; 4Dean's Office, New York University, New York, NY, USA; 5Radiology and Neurology, New York University, New York, NY, USA
Perfusion MRI studies in MS have identified regional areas of decreased perfusion in grey matter (GM) and white matter (WM), but the pattern in clinical subgroups is unclear. Our study investigated global GM and WM perfusion changes in patients with primary-progressing MS (PP-MS) using dynamic susceptibility contrast perfusion MRI and the histogram approach. The results from eight PP-MS patients and eight healthy controls are presented. Although the difference did not reach statistical significance, both global GM and WM perfusion were lower in patients compared to controls. The study is ongoing and data from a larger sample size will be presented.