Abstract #3202

Brain Dynamic Susceptibility Contrast Perfusion Imaging Histograms in Primary Progressive Multiple Sclerosis

Behrang Amini¹, Glyn Johnson², James S. Babb², Joseph Herbert³, Robert I. Grossman⁴, Matilde Inglese⁵

¹Radiology, Tufts Medical Center, Boston, MA, USA; ²Radiology, New York University, New York, NY, USA; ³Neurology, New York University, New York, NY, USA; ⁴Dean's Office, New York University, New York, NY, USA; ⁵Radiology and Neurology, New York University, New York, NY, USA

Perfusion MRI studies in MS have identified regional areas of decreased perfusion in grey matter (GM) and white matter (WM), but the pattern in clinical subgroups is unclear. Our study investigated global GM and WM perfusion changes in patients with primary-progressing MS (PP-MS) using dynamic susceptibility contrast perfusion MRI and the histogram approach. The results from eight PP-MS patients and eight healthy controls are presented. Although the difference did not reach statistical significance, both global GM and WM perfusion were lower in patients compared to controls. The study is ongoing and data from a larger sample size will be presented.