Proton Metabolite Changes in the Corpus Callosum, Thalamus and Brainstem Following Traumatic Brain Injury

Varan Govind¹, Krithica Kaliannan¹, Gaurav Saigal¹, Stuart Gold², Jonathan Jagid³, Leo Harris¹, Andrew A. Maudsley¹

Regions-of-interest analyzes of whole-brain MRSI data from the corpus callosum, thalamus and midbrain indicate significant changes of proton metabolite values or their ratios following traumatic brain injury. Relationships between the metabolite changes and neuropsychological test scores were tested for their associations and found no significant correlations between them, suggesting that the underlying metabolite alterations in these structures cannot be specifically associated with cognitive deficits as determined from the neuropsychological testing.