Meeting Banner
Abstract #3211

Comparison of Myelin Water Fraction in Cross-Regularized T1-Relaxograms of Normal White Matter at 3T and 7T and of Normal-Appearing White Matter at 3T

Christian Labadie1,2, Derek V. Ott1, Thies H. Jochimsen1, Jing-Huei Lee3, Harald E. Mller1,2

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany; 2Faculty of Physics and Earth Science, University of Leipzig, Germany; 3Biomedical Engineering, University of Cincinnati, OH, USA

The myelin water fraction (MWF) measured by cross-regularized T1-relaxography exhibits an increase between 3T and 7T in the white matter of a healthy volunteer. The field dependency of MWF and T1 allowed an estimation of the exchange of water between myelin and the axonal space with a mean resident time of water in myelin of 666.4 369.5 ms. A preliminary study of lesions and normal-appearing white matter in an MS-patient suggests a slight change in the bimodal distribution of MWF.