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Abstract #3254

Atrophy and Shape Changes in Deep Gray Matter in Multiple Sclerosis: A Tensor Based Morphometry

Guozhi Tao1, Sushmita Datta1, Renjie He1, Ponnada A. Narayana1

1Department of Diagnostic and Interventional Imaging, University of Texas, Medical School at Houston, Houston, TX, USA

Tensor based morphometry was applied to determine the atrophy and shape changes in deep gray matter (DGM) structures in 88 relapsing remitting multiple sclerosis (RRMS) patients. Statistical analysis demonstrates significant atrophy and shape change in several DGM structures. The atrophy and/or shape change of various DGM structures, particularly thalamus, putamen, and caudate nucleus were found to be significantly correlated with expanded disability status score (EDSS).