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Abstract #3256

Sequential Monitoring of Fractional Anisotropy (FA) and Apparent Diffusion Coefficient (ADC) in an Experimental Model of Demyelination by DTI and DWI

Krithika Balasubramanian1, Uma Sharma1, S Senthil Kumaran1, S Muthuraj2, Dipti N. Prasad2, Naranamangalam R. Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medcial Sciences, New Delhi, Delhi, India; 2Department of Neurobiology, Defence Institute of Physiology & Allied Sciences, Delhi, India

A sequential study of the changes in fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in an LPC induced demyelinating rat model (internal capsule area of rat brain) at various stages of de- and re-myelination was carried out at 4.7 T. Results show that as demyelination progresses, there is an increase in ADC and a decrease in FA indicating damage to the myelin surrounding nerve fibers. Subsequently, these values reach near normal values during remyelination process. The study improved our understanding of the pathophysiology of the de- and re-myelination process.