Contrast Agent Leakage to Lateral Ventricle After Transient Cerebral Ischemia

Aysan Durukan^1,2, Daniel Strbian^1,2, Ivan Marinkovic^1,2, Miia Pitkonen², Eric Pedrono², Usama Abo-Ramadan^1,2, Turgut Tatlisumak^1,2

Using gadolinium-enhanced MRI, we systematically investigated post-ischemic blood-brain barrier and blood-cerebrospinal fluid barrier integrities, in order to explore whether these two barriers of the rat brain respond similarly to transient ischemic insult. Lateral ventricle on the ischemic hemisphere was enhanced as an early and transient phenomenon occurring most often at 0-12 hours after reperfusion, but never seen after 36 hours. This temporal pattern of lateral ventricle enhancement was clearly different then of parenchymal enhancement, which was continuous up to 5 weeks, suggesting a difference in disruption mechanisms of blood-brain and blood-cerebrospinal fluid barriers of the brain.