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Abstract #3270

Simultaneous EEG and MRI in a Rodent Model of Neonatal Hypoxia-Ischemia

Ward Jennekens1,2, Wim M. Otte3, Maurits P.A. van Meer3, Rick M. Dijkhuizen3, Pieter F.F. Wijn1,2

1Medical Physics, Mxima Medical Center, Veldhoven, Netherlands; 2Eindhoven University of Technology, Eindhoven, Netherlands; 3Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands

The aim of this study is to develop protocols for the indication of MRI examinations based on EEG monitoring of neonates at risk of hypoxic-ischemic encephalopathy. A setup has been developed to simultaneously measure MRI and EEG in an experimental neonatal cerebral ischemia model, in order to find a correlation between changes in anatomy (as measured by MRI) and changes in function (as measured by EEG) following a cerebral infarction. With this setup, it was shown possible to follow the anatomical and functional impact of temporary HI-induced damage processes.