Didem Bilensoy Aksoy1, Roland Bammer2, Chitra Venkatasubramanian1, Sandeep N. Gupta3, Michael Mlynash1, Christine A. C. Wijman1
1Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA; 2Department of Radiology, Stanford University, Palo Alto, CA, USA; 3Applied Science Laboratory, General Electric Medical Systems, Baltimore, MD, USA
Dynamic contrast-enhanced (DCE) MRI is proposed as a tool to detect blood-brain barrier (BBB) injury in patients with acute intracerebral hemorrhage (ICH). In this study, DCE MRI and a two-compartment pharmacokinetic model are utilized to quantify BBB leakage one week after ICH onset. A significant increase in BBB permeability is observed in the region immediately surrounding the hematoma.