Abstract #3280

Assesment of Blood-Brain Barrier Injury Following Acute Intracerebral Hemorrhage by DCE MRI

Didem Bilensoy Aksoy¹, Roland Bammer², Chitra Venkatasubramanian¹, Sandeep N. Gupta³, Michael Mlynash¹, Christine A. C. Wijman¹

¹Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA; ²Department of Radiology, Stanford University, Palo Alto, CA, USA; ³Applied Science Laboratory, General Electric Medical Systems, Baltimore, MD, USA

Dynamic contrast-enhanced (DCE) MRI is proposed as a tool to detect blood-brain barrier (BBB) injury in patients with acute intracerebral hemorrhage (ICH). In this study, DCE MRI and a two-compartment pharmacokinetic model are utilized to quantify BBB leakage one week after ICH onset. A significant increase in BBB permeability is observed in the region immediately surrounding the hematoma.