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Abstract #3280

Assesment of Blood-Brain Barrier Injury Following Acute Intracerebral Hemorrhage by DCE MRI

Didem Bilensoy Aksoy1, Roland Bammer2, Chitra Venkatasubramanian1, Sandeep N. Gupta3, Michael Mlynash1, Christine A. C. Wijman1

1Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA; 2Department of Radiology, Stanford University, Palo Alto, CA, USA; 3Applied Science Laboratory, General Electric Medical Systems, Baltimore, MD, USA

Dynamic contrast-enhanced (DCE) MRI is proposed as a tool to detect blood-brain barrier (BBB) injury in patients with acute intracerebral hemorrhage (ICH). In this study, DCE MRI and a two-compartment pharmacokinetic model are utilized to quantify BBB leakage one week after ICH onset. A significant increase in BBB permeability is observed in the region immediately surrounding the hematoma.