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Abstract #3288

Effects of Cortisol on Brain Metabolism: A H-1 Magnetic Resonance Spectroscopy Study at 3.0T

Michael Scheel1, Andreas Stroehle1, Harald Bruhn2

1Clinic for Psychiatry and Psychotherapy, Charite - University Medicine, Berlin, Germany; 2Department of Radiology, Charit - Humboldt University Medical School, Berlin, Germany

A magnetic resonance spectroscopy study at 3 Tesla investigating the effects of cortisol on the concentration of neuronal metabolites. In a two-phase placebo controlled crossover design 21 healthy volunteers have been studied before and after a 4-day intake of 160 mg hydrocortisol or placebo. No evidence for changes due to the corticosteroid intake could be found. These results question some previous results on the same topic.