Meeting Banner
Abstract #3291

Metabolic Profiles in the Brain of a Transgenic Mouse Model of Type 2 Diabetes Assessed Using in Vivo 1H MRS at 9.4 T

Wen-Tung Wang1, Bhumsoo Kim2, Eva Feldman2, In-Young Choi1,3

1Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, USA; 2Department of Neurology, University of Michigan, Ann Arbor, MI, USA; 3Department of Neurology, Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA

Alterations in cerebral metabolism and function have been suggested in type 2 diabetes, particularly in aging. To characterize metabolic abnormalities in the brains with type 2 diabetes, a rodent model for type 2 diabetes (dbdb) was studied in hippocampus and striatum using localized ultra-short echo time 1H MRS. Brain glucose levels were over twofold higher in diabetic mouse, As compared with those in control mice. The dbdb mice also showed significant increases in the levels of ascorbate, myo-inositol and taurine, suggesting alterations in antioxidant defense and osmoregulation. NAA was lower in the dbdb mice, which may indicate neuronal loss and is consistent with findings in diabetic patients.