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Abstract #3296

Evolution of the Neurochemical Profile in the Frontal and Occipital Cortex of the Developing Mouse Determined by in Vivo 1H NMR Spectroscopy at 14.1 T

Joo M. N. Duarte1, Anita Frank2, Kim Q. Do2, Rolf Gruetter1,3

1LIFMET - CIBM, EPFL, Lausanne, Vaud, Switzerland; 2Schizophrenia Research Unit, Center for Psychiatric Neuroscience, Univ. Hosp. Lausanne, Switzerland; 3Departments of Radiology, Universities of Lausanne and Geneva, Switzerland

The present study investigated the development of the neurochemical profile composed by 20 metabolites in the frontal and occipital cortex of mice, using in vivo 1H NMR spectroscopy at 14.1T. The present data opens the possibility of studying the neurochemical profile evolution in transgenic mice modelling pathologies of the developing brain.