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Abstract #3299

Measurements of Glial Metabolic Fluxes with 11C-Acetate Using Positron Emission and 1H{13C} NMR Spectroscopy

Bernard Lanz1, Lijing Xin1, Matthias T. Wyss2, Bruno Weber2,3, Alfred Buck2, Rolf Gruetter1,4

1Laboratory for functional and metabolic imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2PET Center, University Hospital Zurich, Division of Nuclear Medicine, Zurich, Switzerland; 3Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland; 4Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Metabolic models used to quantify NMR labeling studies and PET results are usually different, based on the fundamentally different nature of the measured signal. We present here an adapted two-compartment model, based on standard NMR modeling, suitable for brain acetate metabolism studies and applicable both to positron emission and NMR measurements. The model enables the fit of both 1H{13C} NMR spectroscopy and beta-probe data and shows a good agreement in the values found for the apparent glial Krebs cycle rate.