Songfan Xu1, Geon-Ho Jahng2, Norbert Schuff3, Dieter J. Meyerhoff4, Michael W. Weiner4
1Department of Medical Research Center, Kyung-Hee University, Seoul, Korea; 2Radiology, East West Neo Medical Center, Kyung Hee University, Seoul, Korea; 3Radiology, CIND, Veterans Affairs Medical Center, UCSF, San Francisco, CA, USA; 4Radiology, CIND, Veterans Affairs Medical Center, UCSF, San Francisco, CA, Korea
To evaluate the susceptibility-induced effects on DTI indexes in patients with Alzheimers disease (AD) and mild cognitive impairment (MCI), we obtained mean diffusivity (MD) and FA maps with using two polarities of diffusion-sensitizing gradients for AD, MCI patients, and cognitive normal (CN) controls. After finding the locations of differences of MD or FA maps between two polarities, we specified the region of interest (ROI) at the locations, and got signals from raw DTI data for ROI and the opposite location in the same samples as well as for ROI in all three groups to compare.