Michal Bittsansky1,2, Stefan Sivak1, Hubert Polacek1,3, Monika Turcanova-Koprusakova1, Egon Kurca1, Dusan Dobrota1
1Jessenius Faculty of Medicine, Comenius
University, Martin, Slovakia; 2MR Centre of Excellence, Medical
University of Vienna, Vienna, Austria; 3Clinic of Radiodiagnostics,
Martin Faculty Hospital, Martin, Slovakia
We compared 1H MR-spectra from different regions along the pyramidal tract of ALS patients to healthy volunteers and to the patients’ clinical score of the disease (ALSFRS). We found significantly different values of NAA:Cre and NAA:Cho in certain brain regions of ALS patients compared to healthy controls. We also found high correlation of NAA:Cre in the right motoric area of the brain to the patients’ ALSFRS score and its subscores for fine and gross motorics.