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Abstract #3325

Proton Magnetic Resonance Spectroscopy Along the Pyramidal Tract of Patients with Amyotrophic Lateral Sclerosis

Michal Bittsansky1,2, Stefan Sivak1, Hubert Polacek1,3, Monika Turcanova-Koprusakova1, Egon Kurca1, Dusan Dobrota1

1Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia; 2MR Centre of Excellence, Medical University of Vienna, Vienna, Austria; 3Clinic of Radiodiagnostics, Martin Faculty Hospital, Martin, Slovakia

We compared 1H MR-spectra from different regions along the pyramidal tract of ALS patients to healthy volunteers and to the patients’ clinical score of the disease (ALSFRS). We found significantly different values of NAA:Cre and NAA:Cho in certain brain regions of ALS patients compared to healthy controls. We also found high correlation of NAA:Cre in the right motoric area of the brain to the patients’ ALSFRS score and its subscores for fine and gross motorics.