Correcting for Partial Volume Effects in Arterial Spin Labeling Perfusion Imaging of Alzheimer's Disease

Iris Asllani¹, Christian G. Habeck, Nicolaos Scarmeas, Truman R. Brown, Yaakov Stern

Pure gray matter CBF images, independent of voxel tissue heterogeneity, were obtained using partial volume corrected arterial spin labeling (ASL) MRI from patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) and compared with those from age-matched healthy controls (HC). Results from ROI and voxelwise analysis are shown. We also investigated the effects of gender and brain atrophy on the observed CBF differences among the three groups.