Abstract #3344

High B-Value Cerebral DWI and Basal Nuclei ADC Measurements in Variant and Sporadic Creutzfeldt-Jakob Disease

Harpreet Hyare^1,2, John Thornton^2,3, Durrenajaf Siddique¹, John Stevens², John Collinge¹, Tarek Yousry^2,3, Rolf Jager^2,3

¹MRC Prion Unit, UCL Institute of Neurology, London, UK; ²Academic Neuroradiological Unit, UCL Institute of Neurology, London, UK; ³Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, UK

The purpose of this study was to investigate whether DWI at high b value (b=3000s/mm2) and ADC measurements in the basal nuclei, improve the diagnosis of variant CJD and sporadic CJD compared to DWI at b=1000s/mm2. At high b value, we found that signal change is more conspicuous, improving confidence in the radiological diagnosis of human prion disease. Regional cerebral ADC changes in prion disease patients compared to controls were demonstrated, the anatomical ADC patterns being different in sporadic and variant CJD. Our results suggest that high-b value DWI provides additional pathological sensitivity in prion diseases.