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Abstract #3363

Abnormal Neural Activity in Treatment-Resistant Depression: A Resting-State FMRI Study

Qi-Zhu Wu1, Dongming Li1, Hong Yang1, Long Chen1, Xiuli Li1, Fei Li1, Nabin Amatya1, Hehan Tang1, Yu-Feng Zang2, Qiyong Gong1

1Huaxi MR Research Center, Department of Radiology, West China Hoapital, Sichuan University, Chengdu, Sichuan, China; 2State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

We performed a resting-state fMRI (rfMRI) study on a group treatment resistant depressive (TRD) patients with age/sex-matched controls. Using the functional data analytical method Regional Homogeneity (ReHo), we characterized an increased ReHo value in the anterior cingulate (ACC) and decreased ReHo value in right inferior parietal lobule. The individual ReHo value in the ACC area was negatively correlated with patient's Hamilton Score. Our work suggested the usefulness of rfMRI and ReHo method in investigating psycho-pathological mechanisms of TRD.