Abstract #3371

A Multimodal Imaging Approach to Surgical Planning in Temporal Lobe Epilepsy

Jodie Reanna Gawryluk^1,2, Ryan C. N. D'Arcy^3,4, David B. Clarke⁵, Kimberly D. Brewer^3,6, Steven D. Beyea^3,6, R M. Sadler⁷, Donald F. Weaver⁷

¹Institute for Biodiagnostics (Atlantic), National Research Council , Halifax, Nova Scotia, Canada; ²Psychology, Dalhousie University, Halifax, Nova Scotia, Canada; ³Institute for Biodiagnostics (Atlantic), National Research Council, Halifax, Nova Scotia, Canada; ⁴Radiology, Dalhousie University, Halifax, Nova Scotia, Canada; ⁵Surgery, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada; ⁶Physics and Atmospheric Science, Dalhousie University, Halifax, Nova Scotia, Canada; ⁷Neurology, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada

Neurosurgical planning can benefit greatly from functional brain imaging. Unfortunately, application in temporal lobe epilepsy must contend with the challenge of deriving clinically relevant data from the complex networks that support high level cognitive processing. The current study uses a multimodal approach that combines high-field functional magnetic resonance imaging (fMRI) and high-density event-related brain potentials (ERPs). fMRI is used in a site-directed fashion to test for spatial differences in activation across medial and lateral regions of the temporal lobes. ERPs, on the other hand, are used in a process-specific fashion to evaluate cognitive processing associated with the temporal lobes.