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Abstract #3377

Hyperoxia Calibrated FMRI of Cerebral Small Vessel Disease During a Cognitive Stroop Task

Jonathan Goodwin1, Guy Lumley1, Andrew Irwin1, Hedley Emsley2, Laura Michelle Parkes1,3

1MARIARC, University of Liverpool, Liverpool, Merseyside, UK; 2Department of Neurology, Royal Preston Hospital, Preston, UK; 3Imaging Science and Biomedical Engineering, University of Manchester, Manchester, UK

In this work we show preliminary results for a study exploring hyperoxia calibrated fMRI, as a novel imaging technique for cerebral small vessel disease (cSVD). 6 lacunar stroke patients with symptomatic cSVD, and 15 healthy aged matched control subjects performed cognitive Stroop task and hyperoxia calibration scans. We found the BOLD response to the Stroop task was higher in the frontal cortices for the SVD group, which corresponded with reduced values of bCMRO2 in those regions. We also found higher average values for the calibration parameter 'A' in all ROIs for the patients compared to the controls.