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Abstract #3382

Altered Brain Connectivity with Hippocampus in Patients with Major Depressive Disorder

Junran Zhang1, XiaoQi Huang1,2, Su Liu1, Qi-Zhu Wu1, Dongming Li1, Long Chen1, Xiuli Li1, Fei Li1, Nabin Amatya1, Hehan Tang1, Weihong Kuang2, QiYong Gong1,2

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, ChengDu, SiChuan Province, China; 2Department of Psychiatry, West China Hospital of Sichuan University

In the present study we used a functional connectivity analysis toolkit REST implemented in Statistical Parametric Mapping software (SPM2) to analyze the resting state functional data obtained from patients with major depression. We chose the hippocampus as the seed region to perform the analysis to investigate its role in mediating the abnormal neural circuit underlies major depression. We identified decreased functional connectivity between the bilateral hippocampus and several cerebral regions in major depressed patients compared with healthy controls.