Abstract #3387

Integrity of Limbic System Network in Schizophrenia: A Tract-Specific Analysis

Akira Kunimatsu¹, Natsuko Kunimatsu², Shigeki Aoki^1,3, Osamu Abe¹, Yoshitaka Masutani¹, Hidenori Yamasue⁴, Kiyoto Kasai⁴, Harushi Mori¹, Daisuke Itoh², Kuni Ohtomo¹

¹Department of Radiology, University of Tokyo, Tokyo, Japan; ²Graduate School of Medicine, University of Tokyo, Tokyo, Japan; ³Department of Radiology, Juntendo University, Tokyo, Japan; ⁴Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan

We aimed to seek diffusion abnormalities of white matter tracts included in the limbic system in schizophrenic patients on a diffusion tensor tract-specific basis. We found significant decreases of fractional anisotropy in the anterior cingulum bundles, the uncinate fasciculi, and the fornices in schizophrenic patients. Our results suggest that disintegration of limbic system network could be monitored by diffusion tensor imaging.