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Abstract #3401

Diffusion Tensor Imaging Tractography of the Corticosomatosensory Pathway in Painless Diabetic Neuropathy

Michael E. Hutton1,2, Dinesh Selvarajah1, Soloman Tesfaye1, Iain D. Wilkinson1,2

1Sheffield Teaching Hospitals NHS Trust, Sheffield, South Yorkshire, UK; 2Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, UK

Diffusion tensor imaging tractography can be used to reconstruct models of complex white matter tracts in the CNS. Quantitative measures such as the number of fibers represented in the model, the fractional anisotropy and the apparent diffusion coefficient can be used to investigate pathologies such as diabetic neuropathy (DN), which have previously been shown to have CNS involvement. In this study we compared a healthy subject group with a DN group and identified possible differences in the corticospinal pathway in the DN group.