Abstract #3404

Neurocognitive Dysfunction in Chornic Kidney Disease (CKD) Patients - Correlations with DTI

Jiachen Zhuo¹, Stephen Seliger², David Lefkowitz¹, Joshua Betz^1,3, Steven Roys¹, Rao Gullapalli¹

¹Radiology, University of Maryland School of Medicine, Baltimore, MD, USA; ²Nephrology, University of Maryland School of Medicine, Baltimore, MD, USA; ³Statistics, University ofMaryland Baltimore County, Baltimore, MD, USA

The purpose of this study was to determine whether alterations in white matter accounts for lower neurocognitive function in CKD patients. Multiple neuro-cognitive assessment scores from 41 stage 3-4 CKD patients were correlated with DTI parameters using whole-brain/regional analysis and voxel-based morphometry. Lower FA and higher ADC were associated with poor performance on various cognitive tests. An alteration to white matter structure, possibly due to generalized microvascular disease may in part explain the observed pattern of cognitive decrement.