Localization and Quantification of Injured Regions and Affected Pathways in the 3D Head-Space of Individual TBI Subjects Using DTI Tractography with Automatically Generated ROIs

Manbir Singh¹, Jeong-Won Jeong¹

Normalized DTI tractography was conducted in the native space of 12 TBI and 10 age-matched control subjects using the same number of seeds in each subject, distributed at anatomically equivalent locations. Whole-brain tracts from the control group were mapped onto the head of each TBI subject. Differences in FA maps between each TBI subject and the control group were computed in a common space using a t-test, transformed back to the individual TBI subjects head-space, and thresholded to form ROIs automatically that were used to sort tracts from all subjects and to compute various diffusion anisotropy metrics.