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Abstract #3422

Study of the Development of Major Cerebral Fiber Bundles and Its Lateralization from Birth to Adulthood Using Quantitative Diffusion Tensor Tractography (DTT)

Richa Trivedi1, Gyanendra K. Malik2, Shruti Agarwal3, Sona Saksena1, Ram K S Rathore3, Rakesh K. Gupta1

1Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Pediatrics, Chattrapati Sahuji Maharaj Medical University, Lucknow, India; 3Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, India

The aim of our study was to compare 3 dimensional axonal growth with age among major fiber bundles using DTT and also to detect cerebral laterality in terms of anatomy, if any. DTI were performed on forty-five right-handed normal human brain with age group ranging from 10 days to 38 years. FA was highest in corpus callosum (CC) followed by inferior longitudinal fasciculus (ILF), cingulam (CNG), superior longitudinal fasciculus (SLF), and fornix (Fx). The FA value of the left CNG as well as left SLF was observed to be significantly greater than that of the right CNG and right SLF, respectively. This study demonstrates the normal development of the white matter fiber bundles as well as cerebral lateralization by using quantitative DTT that may be useful for assessing brain maturation in patients with developmental anomalies associated with cerebral white matter.