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Abstract #3424

A Pediatric Brain Template for Diffusion Tensor Imaging

Zhiyue J. Wang1,2, Jonathan M. Chia3, Michael C. Morriss1,2, Hao Huang4, Barjor Gimi1,2, Nancy K. Rollins1,2

1University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Radiology, Children's Medical Center, Dallas, TX, USA; 3Philips Healthcare, Cleveland, OH, USA; 4Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

A template for diffusion tensor imaging of the brain is constructed from a group of normal children 6 to 18 years of age. The template is constructed by affine transfer of the DTI data for individual subjects to MNI152 space, and averaging the diffusion tensor. Difference maps between patients and the template can be generated to reveal abnormalities in fiber directions. It can also be used with TBSS for pediatric populations. There are clearly noticeable differences in the size of various brain structures between an adult DTI template and the pediatric DTI template in the MNI152 space.