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Abstract #3428

Role of DTI in Understanding Pathophysiology and Assessing Therapeutic Response in Patients with Tuberculous Meningitis (TBM)

Abhishek Yadav1, Chaynika Chaudhry1, Anuradha HK2, Atul Agrawal2, Sanjay Verma3, Ram K S Rathore3, Rakesh K. Gupta1

1Departments of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Neurology, Chhatrapati Sahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 3Department of Mathematics and Statistics, Indian Institute of Technology, Kanpur, Uttar Pradesh, India

DTI was performed in 25 patients with TBM. The diagnosis of TBM was based on Polymerase Chain Reaction, IgM, biochemistry and cytology of cerebral spinal fluid (CSF). ELISA was used to quantify pro-inflammatory molecules (PMs) (sICAM, TNF-, IL-1) in CSF collected on lumber puncture of TBM patients. FA, MD and Signal intensity values were measured by placing region of interests on cortical and basal meninges of both patients and controls. Significant correlation was observed between PMs quantified from CSF and FA values and signal intensity from cerebral cortical as well as basal meninges. We conclude that DTI metrics helps in understanding the pathophysiology of the disease and may be useful in monitoring the effect of antimicrobial therapy in TBM patients.