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Abstract #3442

Functional MRI in Pediatric Cancer Survivors During Cognitive Remediation

Ping Zou1, Raymond Mulhern1, Robert Butler2, Robert Ogg1

1St. Jude Children's Research Hospital, Memphis, TN, USA; 2Oregon Health & Science University, Portland, OR, USA

Patterns of brain activation during a modified Conners Continuous Performance Test (CPT) were measured in childhood cancer survivors who participated in a phase III clinical trial of the Cognitive Remediation Program (CRP). This pilot study showed that fMRI is feasible in childhood cancer survivors during remediation. Differences in activation between patients and healthy children and changes in patterns of activation in patients following remediation suggest that fMRI will help to understand cognitive deficits that these survivors suffer and yield insights into the neural basis of response to remediation.