Meeting Banner
Abstract #3450

Abnormal Cortical and Subcortical Water Diffusivity Measured in Children with Tourette Syndrome.

Malek I. Makki1, Benjamin J. Wilson2, Rajkumar Munian Govindan2, Michael E. Behen3, Harry T. Chugani2

1Radiology, Wayne State University, Detroit, Mi, USA; 2Pediatrics, Wayne State University, Detroit, Mi, USA; 3Psychology, Wayne State University, Detroit, Mi, USA

We used voxel-based-analysis to measure ADC of cortical and subcortical regions within the fronto-striato-thalmo-cortical circuit of 17 right-handed children with Tourette Syndrome and 14 age-matched right-handed controls. Tic severity, hyperactivity, attention, externalizing, internalizing, and obsessive and compulsive problems, were noted. Significant increases of ADC were observed in left and right putamen (p=0.005, p=0.039), orbitofrontal (p=0.017, p=0.007), insular (p=0.008, p=0.021) and left globus pallidus and anterior cingulate (p=0.024, p=0.046). Furthermore, the ADC from right orbitofrontal cortex showed significant positive correlation with the internalizing problem scores (p=0.006).