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Abstract #3463

White Matter Lesions and Cerebral Perfusion Imaging in Late-Onset Major Depression

Rikke Beese Dalby1, Jamila Ahdidan1, M. Mallar Chakravarty2,3, Leif Srensen4, Raben Rosenberg1, Leif stergaard2, Poul Videbech1

1Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark; 2Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark; 3PET Center, Aarhus University Hospital, Aarhus, Denmark; 4Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark

Neuroimaging studies in major depression (MD) have revealed an increased frequency of cerebral white matter lesions (WMLs) and abnormalities in regional cerebral blood flow (CBF) in multiple fronto-limbic structures, which may cause cognitive dysfunction. However, the impact of WMLs on the neuronal network and the concurrent role of cerebral perfusion are not yet fully understood.

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