White Matter Lesions and Cerebral Perfusion Imaging in Late-Onset Major Depression

¹Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark; ²Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark; ³PET Center, Aarhus University Hospital, Aarhus, Denmark; ⁴Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark

Neuroimaging studies in major depression (MD) have revealed an increased frequency of cerebral white matter lesions (WMLs) and abnormalities in regional cerebral blood flow (CBF) in multiple fronto-limbic structures, which may cause cognitive dysfunction. However, the impact of WMLs on the neuronal network and the concurrent role of cerebral perfusion are not yet fully understood.